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KMID : 0604520080340030209
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Journal of the Society of Cosmetic Scientists of Korea
2008 Volume.34 No. 3 p.209 ~ p.215
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Preparation of Micronized Anti-dandruff Agents Using Supercritical Carbon Dioxide
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Shin Moon-Sam
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Abstract
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Iodopropynyl butylcarbamate and climbazole as anti-dandruff agents widely used in cosmetics and pharmaceutics were micronized using supercritical fluid. Supercritical carbon dioxide was selected due to relatively low critical temperature and critical pressure. Iodopropynyl butylcarbamate and climbazole were chosen because of their solubility in supercritical carbon dioxide. The rapid expansion of supercritical solution (RESS) experiments involved investigations of the effect of pressure, temperature on particle size and morphology.
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KEYWORD
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supercritical fluid, micronization, anti-dandruff, IPBC, climbazole
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